[慢性肝病中的肝细胞膜自身抗体（LMA）]
[Liver cell membrane autoantibody (LMA) in chronic liver disease].
作者信息
Garagnani M, Meliconi R, Mazzoli M, Stancari V, Mariani A R, Morabito F, Miglio F, Facchini A
出版信息
Boll Soc Ital Biol Sper. 1980 Aug 15;56(15):1585-9.
The incidence of LMA, detected by indirect IF on isolated rabbit hepatocytes, was significantly higher in CAH-non B (58%) than in CAH-B (15%). Sera from AVH patients showed a smaller percentage of positivity whereas the CPH patients were negative. The organ-specificity, the high incidence in relation to other non-organ-specific autoantibodies and the inverse correlation with the markers of HB Virus, make LMA a specific and sensitive marker of "autoimmune" chronic liver disease.
通过间接免疫荧光法在离体兔肝细胞上检测到的肝细胞膜抗体（LMA）发生率，在非乙型慢性活动性肝炎（CAH-non B）患者中（58%）显著高于乙型慢性活动性肝炎（CAH-B）患者（15%）。急性病毒性肝炎（AVH）患者血清的阳性率较低，而慢性持续性肝炎（CPH）患者血清呈阴性。LMA的器官特异性、相对于其他非器官特异性自身抗体的高发生率以及与乙肝病毒标志物的负相关，使其成为“自身免疫性”慢性肝病的特异性和敏感标志物。
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