Di Sipio L, Piccolomini R, Comanducci A, Favalli C, Iezzi T
Boll Soc Ital Biol Sper. 1980 Sep 15;56(17):1758-64.
Studies were carried out on the combination, 1:1 ratio, of two antibiotics: cephapirin and dicloxacillin. After the analysis of the activity spectrum "in vitro" of each antibiotics, the synergism of this combination against the Gram-negative bacteria strains was clearly demonstrated. This combination demonstrated a particular activity against the beta-lactamases producing strains "in vitro" as well in protection tests "in vivo" in experimental infections in mice.
对两种抗生素头孢匹林和双氯西林按1:1比例组合进行了研究。在分析每种抗生素的“体外”活性谱后，明确证明了该组合对革兰氏阴性菌菌株具有协同作用。在小鼠实验性感染的“体内”保护试验以及“体外”试验中，该组合对产生β-内酰胺酶的菌株均表现出特殊活性。
