[去神经支配及切断-去神经支配大鼠骨骼肌静息膜电位的变化]

[Variations in the resting membrane potential of denervated and tenotomized-denervated rat skeletal muscles].

作者信息

Danieli Betto D, Noventa D

出版信息

Boll Soc Ital Biol Sper. 1980 Oct 30;56(20):2049-55.

Abstract

Resting membrane potential (RMP) was studied in denervated (D), tenotomized (T) and tenotomized-denervated (TD) Soleus (S) and Tibialis Anterior (TA) muscles of the rat. In TD muscles, denervation was performed 1 week after tenotomy. The measurements were performed "in vitro" at 20 degrees C, 1-7 days after denervation in D and TD muscles, and 7 days after tenotomy in T muscles. In T muscles there were not differences in comparison with the controls. In D muscles RMP decreased earlier in S than in TA. The time course of membrane depolarization was similar in TD and D muscles until the 2nd day after denervation. At the 3rd day, RMP showed a further, significant reduction in TD muscles, both in S and TA, but not in D muscles. In D muscles, the depolarization increased very slowly up to the 7th day.

摘要

研究了大鼠去神经支配（D）、切断肌腱（T）和切断肌腱后去神经支配（TD）的比目鱼肌（S）和胫骨前肌（TA）的静息膜电位（RMP）。在TD肌肉中，去神经支配在切断肌腱1周后进行。测量在20℃“体外”进行，D和TD肌肉在去神经支配后1 - 7天进行，T肌肉在切断肌腱后7天进行。与对照组相比，T肌肉没有差异。在D肌肉中，S肌的RMP比TA肌更早降低。直到去神经支配后第2天，TD和D肌肉的膜去极化时间进程相似。在第3天，TD肌肉（S肌和TA肌）的RMP进一步显著降低，但D肌肉没有。在D肌肉中，去极化直到第7天一直非常缓慢地增加。