Danieli Betto D, Midrio M
Arch Sci Biol (Bologna). 1978 Jan-Dec;62(1-4):31-9.
Isometric contraction time (CT), half relaxation time (1/2 RT), tetanus fusion frequency (TFF) and tetanus: twitch ratio (T : t ratio) were measured in the denervated (D) and tenotomized-denervated (TD) Soleus muscle of the rat. In D muscle there was an apparent speeding effect at the 2nd day after denervation, with a significant decrease of CT, which was followed by the usual slowing process of denervated muscle. In TD muscle, denervation was performed a week after tenotomy. Tenotomy "per se" was ineffective in modifying dynamic properties of muscle, but it accentuated the early shortening of CT caused by denervation, while reducing and delaying the subsequent slowing process. The results are discussed in the light of the hypothesis that muscle disuse has a speeding effect which counteracts the slowing effect of denervation, and/or that tenotomy modifies the effects of denervation by changing the pattern of fibrillation development.
在大鼠的失神经支配（D）和切断肌腱 - 失神经支配（TD）的比目鱼肌中测量等长收缩时间（CT）、半松弛时间（1/2 RT）、强直融合频率（TFF）和强直：单收缩比率（T：t比率）。在D组肌肉中，失神经支配后第2天出现明显的加速效应，CT显著降低，随后是失神经支配肌肉通常的减慢过程。在TD组肌肉中，切断肌腱一周后进行失神经支配。切断肌腱“本身”对改变肌肉的动态特性无效，但它加剧了失神经支配引起的CT早期缩短，同时减少并延迟了随后的减慢过程。根据肌肉废用具有加速效应从而抵消失神经支配的减慢效应这一假设，和/或切断肌腱通过改变肌纤颤发展模式来改变失神经支配的效应，对结果进行了讨论。
