单独使用阿霉素或联合放疗治疗后肠道隐窝的存活率。
Survival of intestinal crypts after treatment by adriamycin alone or with radiation.
作者信息
Moore J V, Broadbent D A
出版信息
Br J Cancer. 1980 Nov;42(5):692-6. doi: 10.1038/bjc.1980.303.
Abstract
A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.
摘要
已建立了经腹腔单次注射抗生素阿霉素处理的BDF1小鼠空肠隐窝的存活曲线。阈值剂量和Do是这些小鼠骨髓CFU-S的两倍。与γ射线辐射的值相比，隐窝存活曲线的总体外推数非常低（1.3±0.13）。结合隐窝存活曲线的解释对该观察结果进行了讨论。我们未能证明阿霉素对紧接药物给药前给予的辐射的微集落形成细胞反应有任何增强作用（Dq降低）。
相似文献
1
Survival of intestinal crypts after treatment by adriamycin alone or with radiation.单独使用阿霉素或联合放疗治疗后肠道隐窝的存活率。
Br J Cancer. 1980 Nov;42(5):692-6. doi: 10.1038/bjc.1980.303.
2
3
Interactions of radiation and adriamycin, bleomycin, mitomycin C or cis-diamminedichloroplatinum II in intestinal crypt cells.辐射与阿霉素、博来霉素、丝裂霉素C或顺二氯二氨铂II在肠隐窝细胞中的相互作用。
Br J Cancer. 1984 Jun;49(6):779-86. doi: 10.1038/bjc.1984.121.
4
5
Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate.人参和二乙基二硫代氨基甲酸盐对小鼠辐射反应的影响
In Vivo. 2001 Sep-Oct;15(5):407-11.
6
Damage and recovery assessment of the mouse jejunum to abdominal X-ray and adriamycin treatment.
Br J Radiol. 1975 Nov;48(575):908-12. doi: 10.1259/0007-1285-48-575-908.
7
Dose and time effects of cis-diamminedichloroplatinum(II) and radiation on mouse duodenal crypts.
Radiother Oncol. 1985 Dec;4(4):363-71. doi: 10.1016/s0167-8140(85)80124-9.
8
Combined effect of procarbazine and ionizing radiation on mouse jejunal crypts.
Chemotherapy. 1978;24(6):368-73. doi: 10.1159/000237810.
9
Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.化疗药物治疗后肠隐窝及其组成细胞的死亡。
Br J Cancer. 1984 Jan;49(1):25-32. doi: 10.1038/bjc.1984.5.
10
Interactions of radiation and 5-fluorouracil, cyclophosphamide or methotrexate in intestinal crypt cells.
Int J Radiat Oncol Biol Phys. 1984 Jan;10(1):77-86. doi: 10.1016/0360-3016(84)90415-2.
引用本文的文献
1
Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.化疗药物治疗后肠隐窝及其组成细胞的死亡。
Br J Cancer. 1984 Jan;49(1):25-32. doi: 10.1038/bjc.1984.5.
2
Interactions of radiation and adriamycin, bleomycin, mitomycin C or cis-diamminedichloroplatinum II in intestinal crypt cells.辐射与阿霉素、博来霉素、丝裂霉素C或顺二氯二氨铂II在肠隐窝细胞中的相互作用。
Br J Cancer. 1984 Jun;49(6):779-86. doi: 10.1038/bjc.1984.121.
本文引用的文献
1
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
Radiat Res. 1961 Feb;14:213-22.
2
Computer programmes for fitting Puck and probit survival curves.用于拟合Puck和概率单位生存曲线的计算机程序。
Int J Radiat Biol Relat Stud Phys Chem Med. 1969;16(4):323-32. doi: 10.1080/09553006914551351.
3
Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation.小鼠肠道黏膜细胞辐射后的微菌落存活试验
Int J Radiat Biol Relat Stud Phys Chem Med. 1970;17(3):261-7. doi: 10.1080/09553007014550291.
4
Cryptogenic cells and proliferative cells in intestinal epithelium.肠道上皮中的隐源性细胞和增殖性细胞。
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Jun;25(6):583-8. doi: 10.1080/09553007414550771.
5
Letter: Effects of adriamycin on the radiation response of murine hematopoietic stem cells.信函：阿霉素对小鼠造血干细胞辐射反应的影响。
Radiat Res. 1976 Jul;67(1):162-7.
6
The interaction between radiation and adriamycin damage in mammalian cells.
Cancer Res. 1977 Jun;37(6):1624-30.
7
The effects of X-irradiation and adriamycin on proliferating and nonproliferating hair coat of the mouse.
Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1261-4. doi: 10.1016/0360-3016(79)90650-3.
8
Cell-survival characteristics of intestinal stem cells and crypts of gamm-irradiated mice.γ射线照射小鼠肠道干细胞和隐窝的细胞存活特征
Radiat Res. 1979 Oct;80(1):92-107.
9
Cytotoxic effects of chemotherapeutic drugs on mouse testis cells.
Cancer Res. 1979 Sep;39(9):3575-82.
10
The effects of adriamycin and X-irradiation on the murine duodenum.
Int J Radiat Oncol Biol Phys. 1979 Apr;5(4):507-13. doi: 10.1016/0360-3016(79)90814-9.
Zotero 插件