Moore J V, Broadbent D A
Br J Cancer. 1980 Nov;42(5):692-6. doi: 10.1038/bjc.1980.303.
A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.
已建立了经腹腔单次注射抗生素阿霉素处理的BDF1小鼠空肠隐窝的存活曲线。阈值剂量和Do是这些小鼠骨髓CFU-S的两倍。与γ射线辐射的值相比，隐窝存活曲线的总体外推数非常低（1.3±0.13）。结合隐窝存活曲线的解释对该观察结果进行了讨论。我们未能证明阿霉素对紧接药物给药前给予的辐射的微集落形成细胞反应有任何增强作用（Dq降低）。
