兔肝脏中不依赖硒的谷胱甘肽过氧化物酶活性
Selenium-independent glutathione peroxidase activity in rabbit liver.
作者信息
Morrissey P, O'Brien P J
出版信息
Can J Biochem. 1980 Oct;58(10):1012-7. doi: 10.1139/o80-137.
The reduction of linoleic acid hydroperoxide catalyzed by rat liver cytosol was previously shown to be catalyzed by a selenium-dependent glutathione peroxidase. In contrast, the activity in rabbit liver cytosol could also be attributed to a selenium-dependent peroxidase. The selenium-independent peroxidase copurified with glutathione transferase B and was completely inhibited by antitransferase B antiserum and transferase substrates. These results suggest that glutathione transferase B in rabbit liver cytosol is involved in the intracellular decomposition of lipid peroxide and could explain the lower selenium requirement of rabbits in comparison with other species.
先前的研究表明，大鼠肝细胞溶胶催化的亚油酸氢过氧化物的还原是由一种硒依赖性谷胱甘肽过氧化物酶催化的。相比之下，兔肝细胞溶胶中的活性也可归因于一种硒依赖性过氧化物酶。与谷胱甘肽转移酶B共纯化的非硒依赖性过氧化物酶被抗转移酶B抗血清和转移酶底物完全抑制。这些结果表明，兔肝细胞溶胶中的谷胱甘肽转移酶B参与了脂质过氧化物的细胞内分解，并且可以解释与其他物种相比，兔子对硒的需求较低。
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