在苄醇中通过与氰化钾进行酯交换反应从苄酯树脂上裂解保护的氨基酸和肽。
Cleavage of protected amino acids and peptides from benzyl ester resins by transesterification with potassium cyanide in benzyl alcohol.
作者信息
Moore G J, Kwok Y C
出版信息
Can J Biochem. 1980 Aug;58(8):641-3. doi: 10.1139/o80-088.
DOI:10.1139/o80-088
PMID:7459690
Abstract
The nature of the protected amino acid or peptide attached to the Merrifield resin influences the rate of KCN-catalyzed transesterification in benzyl alcohol. Although crown ether complexes of KCN do not expedite the reaction, sterically hindered amino acids are readily transesterified in the presence of saturating concentrations of KCN at elevated temperatures.
摘要
连接在梅里菲尔德树脂上的受保护氨基酸或肽的性质会影响在苄醇中KCN催化的酯交换反应速率。尽管KCN的冠醚配合物不会加快反应，但在高温下，在饱和浓度的KCN存在下，空间位阻氨基酸很容易发生酯交换反应。
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