Cass C E, Turner A R, Selner M, Allalunis M J, Tan T H
Cancer Res. 1981 Mar;41(3):1000-5.
Serum concentrations of lithium after i.p. administration to normal mice declined with biphasic kinetics. Treatment of mice bearing ascitic L1210 leukemia with lithium resulted in a modest protection against the myelosuppressive effects of vinblastine. Lithium as a single agent was without effect on the survival times of mice bearing either the L1210 or P388 leukemia. Similarly, there was no evidence of significant antiproliferative or cytotoxic activity when cultured L1210 leukemia and murine neuroblastoma cells were exposed to lithium at levels comparable to those observed in the serum of lithium-treated mice. The therapeutic activity of vinblastine against the L1210 and P388 leukemias was not significantly altered by either simultaneous or subsequent administration of lithium. Lithium did not antagonize the antiproliferative or cytotoxic action of vinblastine against L1210 leukemia or murine neuroblastoma cells and was without effect in experiments with neuroblastoma cells that assessed vinblastine inhibition of a biological function dependent on formation of cytoplasmic microtubules (neurite formation induced by serum deprivation). The results obtained suggest that administration of lithium to reduce myelosuppression is not likely to counteract the tumoricidal activity of vinblastine.
腹腔注射锂后，正常小鼠血清中的锂浓度以双相动力学下降。用锂治疗患有腹水型L1210白血病的小鼠，可适度保护其免受长春碱骨髓抑制作用的影响。锂作为单一药物对患有L1210或P388白血病的小鼠的存活时间没有影响。同样，当将培养的L1210白血病细胞和鼠神经母细胞瘤细胞暴露于与锂治疗小鼠血清中观察到的水平相当的锂时，没有证据表明锂具有显著的抗增殖或细胞毒性活性。长春碱对L1210和P388白血病的治疗活性不会因同时或随后给予锂而发生显著改变。锂不会拮抗长春碱对L1210白血病或鼠神经母细胞瘤细胞的抗增殖或细胞毒性作用，并且在评估长春碱对依赖于细胞质微管形成（血清剥夺诱导的神经突形成）的生物学功能的抑制作用的神经母细胞瘤细胞实验中没有效果。所获得的结果表明，给予锂以减轻骨髓抑制不太可能抵消长春碱的杀肿瘤活性。
