Taylor G N, Gardner P, Mays C W, Wrenn M E, Charrier K
Cancer Res. 1981 Mar;41(3):971-3.
The incidence of bone cancer, after a single i.p. injection of monomeric 239Pu citrate, is significantly higher in female than in male mice. To evaluate the role of the gonads in this sex-related difference, male and female C57BL/Do (albino) mice were castrated at 40 days of age. Fifty days later, they were given injections of 239Pu. After castration, the frequency of bone sarcomas in the two sexes was approximately equal. This resulted from an increased incidence in the castrated males and a decreased incidence in the ovariectomized females as compared to the intact plutonium-treated mice.
单次腹腔注射柠檬酸钚单体后，雌性小鼠的骨癌发病率显著高于雄性小鼠。为评估性腺在这种性别差异中的作用，40日龄的雄性和雌性C57BL/Do（白化）小鼠接受了阉割手术。50天后，给它们注射钚-239。阉割后，两性骨肉瘤的发生率大致相等。这是由于与完整的接受钚处理的小鼠相比，阉割雄性小鼠的发病率增加，而卵巢切除雌性小鼠的发病率降低。
