Cortés-Prieto J, Bosch A O, Rocha J A
Clin Ther. 1980;3(3):200-8.
Allylestrenol was used to treat 375 women with threatened pregnancies. Results show that this drug is capable of maintaining pregnancy in a large series of ambulant patients and is safe for both mother and child. Allylestrenol does not maintain pregnancy if placental dysfunction is present, however. Newborns whose mothers are treated with allylestrenol have slightly higher birth weights than controls. The possible role of allylestrenol in this process is discussed. At high doses, allylestrenol effectively stops premature labor, suggesting a selective action on the myometrium.
烯丙雌醇用于治疗375例有先兆流产的妇女。结果表明，该药能够使大量门诊患者维持妊娠，且对母婴均安全。然而，如果存在胎盘功能不全，烯丙雌醇则无法维持妊娠。母亲接受烯丙雌醇治疗的新生儿出生体重略高于对照组。文中讨论了烯丙雌醇在此过程中的可能作用。高剂量时，烯丙雌醇可有效抑制早产，提示其对子宫肌层有选择性作用。
