Adekunle O O, Abioye A A
Dis Colon Rectum. 1980 Nov-Dec;23(8):559-63. doi: 10.1007/BF02988996.
This paper analyzes 320 cases of colorectal adenocarcinoma at the University College Hospital, Ibadan, Nigeria over a period of 18 years. The sex ratio was 1.5:1 in favor of males; the average age when first seen was 44 years. The symptom complex was weight loss, bloody mucoid stool, altered bowel habit, and abdominal mass. Eighty per cent of rectal cases were in the lower third of the rectum. Most cases were very advanced at the time they were first seen. The association of infective granuloma, notably schistosomiasis and amebiasis, occurred in 11 cases. This probably had diagnostic significance but the etiologic significance is still conjectural. Eighty per cent of the tumors were well-differentiated adenocarcinoma, while 20 per cent were of other histologic variants. In spite of advanced disease, resection was possible in 66 per cent of colonic and 45 per cent of rectal cases. Although the number of cases of colorectal cancers treated yearly in the hospital has increased significantly in the last few years, it is suggested that the hitherto low treatment rate may be attributable to social unacceptability of a permanent colostomy.
本文分析了尼日利亚伊巴丹大学学院医院18年间的320例结肠直肠癌病例。男女比例为1.5:1，男性居多；初诊时的平均年龄为44岁。症状包括体重减轻、血性黏液便、排便习惯改变和腹部肿块。80%的直肠癌病例位于直肠下三分之一处。大多数病例在初诊时已处于非常晚期。11例病例出现了感染性肉芽肿，尤其是血吸虫病和阿米巴病。这可能具有诊断意义，但病因学意义仍属推测。80%的肿瘤为高分化腺癌，20%为其他组织学类型。尽管疾病已处于晚期，但66%的结肠癌病例和45%的直肠癌病例仍可行手术切除。尽管在过去几年中，该医院每年治疗的结肠直肠癌病例数量显著增加，但有人认为，迄今为止较低的治疗率可能归因于永久性结肠造口术在社会上难以被接受。
