Collste L, Berlin T, von Garrelts B, Granberg I, Lewander R
Eur Urol. 1981;7(2):85-8. doi: 10.1159/000473186.
An organic siloxane compound, 2,6-cis-diphenylhexamethylcyclotetrasiloxane, (Cisobitan) has been shown to possess antigonadotropic properties. In this study it has been tried in prostatic cancer. 9 patients received the drug in the dose of 4-5 mg/kg body weight. General condition and subjective response, cytologic changes and semiquantitative scintigraphic changes of metastases were recorded, as well as common laboratory data. In this limited trial, Cisobitan was not adequate for tumour palliation. In a few instances subsequent oestrogen treatment was more effective. No side effects of Cisobitan were noted for periods up to 6 months. Further studies may be of value, perhaps using a higher dose.
一种有机硅氧烷化合物，2,6-顺式-二苯基六甲基环四硅氧烷（西索比坦）已被证明具有抗促性腺激素特性。在本研究中，对其进行了前列腺癌试验。9名患者接受了剂量为4 - 5毫克/千克体重的该药物治疗。记录了患者的一般状况和主观反应、细胞学变化、转移灶的半定量闪烁扫描变化以及常规实验室数据。在这项有限的试验中，西索比坦对肿瘤缓解并不充分。在少数情况下，后续的雌激素治疗更有效。在长达6个月的时间里未观察到西索比坦的副作用。进一步的研究可能有价值，或许可以使用更高的剂量。
