Hara H
Exp Hematol. 1980 Mar;8(3):345-50.
The kinetics of pluripotent hemopoietic precursors (CFUmix) in vitro was studied during erythropoietic stimulation and suppression. Erythropoiesis was stimulated by the subcutaneous injection of 60 mg per kg phenylhydrazine hydrochloride on days 0, 1 and 3. Erythropoiesis was suppressed by transfusion of 1 ml of the packed red cells on three consecutive days. After erythropoietic stimulation, CFUmix were decreased in the femur and increased in the spleen. In contrast, the CFUmix were increased in both the femur and the spleen after suppression of erythropoiesis. The kinetic behavior of CFUmix were similar to those of CFUS reported previously. The behavior of CFUmix during erythropoietic stimulation and suppression revealed another biologic similarity between CFUmix and CFUS, in addition to the similarity of proliferative state and sedimentation velocity.
在红细胞生成的刺激和抑制过程中，对体外多能造血前体细胞（CFUmix）的动力学进行了研究。在第0、1和3天，通过皮下注射每千克60毫克盐酸苯肼来刺激红细胞生成。通过连续三天输注1毫升压积红细胞来抑制红细胞生成。红细胞生成受到刺激后，股骨中的CFUmix减少，脾脏中的CFUmix增加。相比之下，红细胞生成受到抑制后，股骨和脾脏中的CFUmix均增加。CFUmix的动力学行为与先前报道的CFUS相似。除了增殖状态和沉降速度相似之外，CFUmix在红细胞生成的刺激和抑制过程中的行为揭示了CFUmix与CFUS之间的另一种生物学相似性。
