Grözinger K H
Fortschr Med. 1980 Sep 4;98(33):1261-4.
In a prospective study serum and bile cholesterol concentrations were examined in 233 patients with gallstones. The objective of the study was the selection of patients in which conservative dissolution of gallstones might be successful. The average concentration of cholesterol in serum was 227,46 +/- 41,64 mg/100 ml, in gallbladder bile 8,83 +/- 5,66 mg/100 ml. The cholesterol contents of gallstones was 73,47 +/- 19,47 per cent. Statistical relations were found neither between the cholesterol concentrations in serum and bile nor between the cholesterol contents of gallstones and the cholesterol concentrations in serum and bile. The postoperative cholesterol concentration in serum was remarkably diminished as compared with preoperative values in all patients. A statistically significant decrease of serum cholesterol was seen in patients with histologically proven fatty liver disease. Measuring the cholesterol concentration in serum is no appropriate way for the selection of patients with gallstones for a litholytic treatment. It should be evaluated whether a concomitant fatty liver disease is an indication for a therapeutic trial with chenodesoxycholic acid.
在一项前瞻性研究中，对233例胆结石患者的血清和胆汁胆固醇浓度进行了检测。该研究的目的是筛选出胆结石保守溶解可能成功的患者。血清中胆固醇的平均浓度为227.46±41.64mg/100ml，胆囊胆汁中为8.83±5.66mg/100ml。胆结石的胆固醇含量为73.47±19.47%。在血清和胆汁中的胆固醇浓度之间，以及胆结石的胆固醇含量与血清和胆汁中的胆固醇浓度之间均未发现统计学关系。与所有患者的术前值相比，术后血清胆固醇浓度显著降低。在组织学证实为脂肪性肝病的患者中，血清胆固醇有统计学意义的下降。测定血清胆固醇浓度并非选择胆结石患者进行溶石治疗的合适方法。应评估合并脂肪性肝病是否是进行鹅去氧胆酸治疗试验的指征。
