Gillissen G
Immun Infekt. 1980;8(3):79-88.
The clinical effectivity of an antimicrobial chemotherapy substantially depends on a functionally intact immune system. Among the antibiotics, however, there are many which can impair the cellular and/or humoral immune defence. The actually published but by no means complete data of this relatively new field of research suggest that a conconcomitant immunosuppressive effect correlates less with the (as far as known) antibacterial mode of action than--but even here with certain exceptions--with the chemical classification. A clinical significance of these observations seems to be at hand in borderline immunological defence situations. To optimize the antimicrobial chemotherapy, it is becoming evident that only only the sensitivity of the isolated infective agents but also the concomitant effect of antibiotics should be taken into account. There are antibiotics being neutral or even stimulating in respect to the immune system. On the other hand, substances given additionally to antibiotics or certain kinds of treatment have been described equalizing the immunosuppressive effect of antibiotics.
抗菌化疗的临床有效性在很大程度上取决于功能健全的免疫系统。然而，在抗生素中，有许多会损害细胞和/或体液免疫防御。这个相对较新的研究领域实际已发表但远非完整的数据表明，伴随的免疫抑制作用与（就目前所知）抗菌作用方式的相关性，比与化学分类的相关性要小——但即使在这里也有某些例外。在免疫防御处于临界状态的情况下，这些观察结果似乎具有临床意义。为了优化抗菌化疗，越来越明显的是，不仅要考虑分离出的感染因子的敏感性，还要考虑抗生素的伴随效应。有些抗生素对免疫系统是中性的，甚至有刺激作用。另一方面，已经描述了与抗生素联合使用的物质或某些治疗方法可以抵消抗生素的免疫抑制作用。
