Ljunggren B, Bjellerup M, Carter D M
J Invest Dermatol. 1981 Feb;76(2):73-5. doi: 10.1111/1523-1747.ep12525311.
Serum levels and skin photosensitivity following different oral doses of 8-methoxypsoralen (8-MOP) were studied in 8 healthy volunteers. Two hours after ingestion of drug, serum levels of 8-MOP determined by high pressure liquid chromatography correlated well with oral dose. Serum concentrations after 8-MOP doses of 0.3, 0.6 and 0.9 mg/kg bodyweight were 25.9 (+/- 7.2), 148.9 (+/- 24.4) and 311.4 (+/- 55.6) ng/ml (mean and SEM) respectively. The minimal phototoxic dose (MPD) of UVA 2 hr after ingesting 8-MOP was determined in 6 volunteers for each of the 3 before-mentioned 8-MOP doses. The UV-A doses correlated inversely with the serum level for each individual (r = 0.92 +/- 0.02 SEM). For higher 8-MOP doses the numerical product of UV-A dose and 8-MOP serum concentration in each individual tended to be constant, indicating a reciprocal relationship between 8-MOP and UV-A doses in this interval. This did not hold true for the lowest 8-MOP-dose. These data confirm the relevance of using 8-MOP blood level determinations in monitoring psoralen-UV-A phototoxicity.
在8名健康志愿者中研究了不同口服剂量的8-甲氧基补骨脂素（8-MOP）后的血清水平和皮肤光敏感性。服药后两小时，通过高压液相色谱法测定的8-MOP血清水平与口服剂量密切相关。8-MOP剂量分别为0.3、0.6和0.9mg/kg体重时的血清浓度分别为25.9（±7.2）、148.9（±24.4）和311.4（±55.6）ng/ml（均值和标准误）。对于上述3种8-MOP剂量中的每一种，在6名志愿者中测定了摄入8-MOP后2小时的UVA最小光毒性剂量（MPD）。对于每个个体，UV-A剂量与血清水平呈负相关（r = 0.92±0.02标准误）。对于较高的8-MOP剂量，每个个体的UV-A剂量与8-MOP血清浓度的数值乘积趋于恒定，表明在此区间内8-MOP与UV-A剂量之间存在反比关系。最低的8-MOP剂量情况并非如此。这些数据证实了在监测补骨脂素-UV-A光毒性时测定8-MOP血药浓度的相关性。
