Sonnino S, Ghidoni R, Masserini M, Aporti F, Tettamanti G
J Neurochem. 1981 Jan;36(1):227-32. doi: 10.1111/j.1471-4159.1981.tb02398.x.
The present study deals with the developmental profile of cytosolic and membrane-bound gangliosides in rabbit whole brain from the 21st day of pregnancy, the time at which brain could be macroscopically recognized and handled, till birth. In this period of prenatal life the content of membrane-bound gangliosides showed a 2.5-fold increase, referred to fresh and dry brain weight and to membrane-bound protein; the content of cytosolic gangliosides reached a maximum at 21-22 days of pregnancy, and then underwent to birth a threefold diminution. The qualitative pattern of membrane-bound gangliosides, in the same period of life, was characterized by an increase of GD1a and GM1 (more marked for GD1a), a decrease of GT1a, GT1b and GQ1b, and a constant level of GD3 and GD1b. At 21 days of pregnancy the most abundant gangliosides were GT1b and GQ1b, followed by GD1a and GD1b; at birth it was GD1a, followed by GT1b, GD1b and GM1. The qualitative pattern of cytosolic gangliosides closely resembled, during the entire period of prenatal life examined, that of membrane-bound gangliosides.
本研究探讨了从妊娠第21天（此时大脑在宏观上可被识别和处理）直至出生期间，兔全脑中胞质和膜结合神经节苷脂的发育情况。在这个产前阶段，膜结合神经节苷脂的含量以新鲜和干脑重量以及膜结合蛋白为参照，增加了2.5倍；胞质神经节苷脂的含量在妊娠21 - 22天时达到最高，然后在出生前减少了三倍。在同一生命阶段，膜结合神经节苷脂的定性模式表现为GD1a和GM1增加（GD1a增加更明显），GT1a、GT1b和GQ1b减少，GD3和GD1b水平恒定。妊娠21天时，含量最丰富的神经节苷脂是GT1b和GQ1b，其次是GD1a和GD1b；出生时，是GD1a，其次是GT1b、GD1b和GM1。在所研究的整个产前阶段，胞质神经节苷脂的定性模式与膜结合神经节苷脂的定性模式非常相似。
