King C L, Kong Y C, Wong N S, Yeung H W, Fong H H, Sankawa U
J Nat Prod. 1980 Sep-Oct;43(5):577-82. doi: 10.1021/np50011a008.
Rutaecarpine (1) and dehydroevodiamine (2) were isolated from the unripe fruit of Evodia rutaecarpa. In vitro uterotonic assay on rat uterus showed both alkaloids to be active. Dehydroevodiamine was further shown to be active in the in vivo uterotonic assay using rats as the animal model. Reference evodiamine hydrochloride (3) was also evaluated and found to be devoid of uterontonic activity at the doses administered.
吴茱萸次碱（1）和去氢吴茱萸碱（2）是从吴茱萸未成熟果实中分离得到的。对大鼠子宫进行的体外子宫收缩活性测定表明，这两种生物碱均具有活性。使用大鼠作为动物模型进行的体内子宫收缩活性测定进一步表明，去氢吴茱萸碱具有活性。还对参比物质盐酸吴茱萸碱（3）进行了评估，发现在所给药剂量下其没有子宫收缩活性。
