El-Rashidy R, Niazi S
J Pharm Sci. 1980 Dec;69(12):1455-7. doi: 10.1002/jps.2600691233.
The widespread use of butylated hydroxyanisole (I) and butylated hydroxytoluene (II) as food antioxidants recently has been criticized by the Food and Drug Administration because of their pharmacological and toxicological effects. Interest also has arisen recently in the use of these compounds as anticancer agents. The purposes of this study were to evaluate the pharmacokinetics of I and II in rabbits and to compare their physicochemical properties with their disposition kinetics. It was found that I has a disposition half-life of approximately 1 hr, compared to 11 days for II. These differences are explained in terms of their lipid solubility and protein binding characteristics.
近年来，丁基羟基茴香醚（I）和丁基羟基甲苯（II）作为食品抗氧化剂被广泛使用，然而美国食品药品监督管理局因其药理和毒理作用对其提出了批评。近期人们也开始关注将这些化合物用作抗癌剂。本研究的目的是评估I和II在兔子体内的药代动力学，并将它们的理化性质与其处置动力学进行比较。结果发现，I的处置半衰期约为1小时，而II为11天。这些差异可以根据它们的脂溶性和蛋白质结合特性来解释。
