Martin C J, Saxena S J
J Pharm Sci. 1980 Dec;69(12):1459-61. doi: 10.1002/jps.2600691235.
A high-performance liquid chromatographic (HPLC) procedure was developed for the determination of metaraminol bitartrate in the presence of methylparaben and propylparaben. Reversed-phase ion-pair chromatography was employed using dioctyl sodium sulfosuccinate as the counterion. The current official USP procedure for the determination of metaraminol requires dilution, extraction, and measurement of UV absorption. The HPLC procedure is rapid and precise and correlates well with the USP XX procedure. It can be used for metaraminol injectables as well as the raw material.
开发了一种高效液相色谱（HPLC）方法，用于在对羟基苯甲酸甲酯和对羟基苯甲酸丙酯存在下测定重酒石酸间羟胺。采用反相离子对色谱法，使用磺基琥珀酸二辛酯钠作为反离子。目前美国药典测定间羟胺的官方方法需要稀释、萃取和测量紫外吸收。HPLC方法快速、精确，与美国药典XX方法相关性良好。它可用于重酒石酸间羟胺注射液以及原料药。
