Murphy D M, Zincke H, Furlow W L
J Urol. 1981 Jan;125(1):25-9. doi: 10.1016/s0022-5347(17)54881-8.
A total of 175 patients was operated on for grade 2, 3 or 4 transitional cell epithelioma of the upper urinary tract. Followup was between 5 and 26 years. The operations involved total nephroureterectomy, simple nephrectomy and local resection. Patient survival correlated well with tumor stage and, particularly, with tumor grade, and, consistently, was inferior to that of an age and sex-matched control group. The correlation of survival and ipsilateral tumor recurrence with the type of operation suggests that patients with grade 2 tumors may benefit from total nephroureterectomy. The incidence of ipsilateral tumor recurrence (28 per cent) was high in this group. The radical procedure seems to be of no benefit to patients with grade 3 or 4 tumors. The incidence of subsequent bladder tumor was 30 per cent in patients with grades 2 and 3 tumors. The latent period ranged from 2 months to 10 years (average 23 months); 82 per cent of the tumors occurred within 3 years of treatment of the upper tract tumor.
共有175例患者接受了上尿路2级、3级或4级移行细胞上皮瘤手术。随访时间为5至26年。手术方式包括根治性肾输尿管切除术、单纯肾切除术和局部切除术。患者生存率与肿瘤分期密切相关，尤其是与肿瘤分级相关，并且始终低于年龄和性别匹配的对照组。生存率和同侧肿瘤复发与手术类型的相关性表明，2级肿瘤患者可能从根治性肾输尿管切除术中获益。该组同侧肿瘤复发率较高（28%）。根治性手术似乎对3级或4级肿瘤患者无益。2级和3级肿瘤患者后续发生膀胱肿瘤的发生率为30%。潜伏期为2个月至10年（平均23个月）；82%的肿瘤发生在上尿路肿瘤治疗后的3年内。
