Pokracki F J, Robinson A G, Seif S M
Metabolism. 1981 Jan;30(1):72-8. doi: 10.1016/0026-0495(81)90222-5.
The effect of chlorpropamide on neurohypophyseal function was studied by measurement of neurophysin and vasopressin in humans and in rats. Administration of chlorpropamide was shown to inhibit the ability of the human subjects and of the rats to maximally dilute their urine after administration of water. Comparison of the levels of vasopressin and neurophysin before and after the administration of chlorpropamide in the basal state and after water loading in both the human subjects and in rats showed no lack of suppression due to the chlorpropamide. The levels of both peptides were measured at the limits of detection. In other studies where neurophysin and vasopressin were readily detected, administration of chlorpropamide did not result in any augmented release of neurophysin or vasopressin in response to stimulation of the neurohypophysis in humans nor in rats. Levels of neurophysin in the pituitaries of rats showed no change in rats given chlorpropamide, while the content of vasopressin was increased, possibly indicating a chronic decreased secretion of vasopressin in rats given chlorpropamide.
通过测定人和大鼠中神经垂体素和血管加压素，研究了氯磺丙脲对神经垂体功能的影响。结果显示，给予氯磺丙脲后，人类受试者和大鼠最大限度稀释尿液的能力受到抑制。比较人类受试者和大鼠在基础状态下以及饮水负荷后给予氯磺丙脲前后血管加压素和神经垂体素的水平，结果表明氯磺丙脲并未导致抑制不足。两种肽的水平均在检测限处进行测定。在其他易于检测到神经垂体素和血管加压素的研究中，给予氯磺丙脲后，无论是人类还是大鼠，对神经垂体的刺激均未导致神经垂体素或血管加压素的释放增加。给予氯磺丙脲的大鼠垂体中神经垂体素水平未发生变化，而血管加压素含量增加，这可能表明给予氯磺丙脲的大鼠血管加压素分泌长期减少。
