Sinding C, Seif S M, Robinson A G
Endocrinology. 1980 Sep;107(3):749-54. doi: 10.1210/endo-107-3-749.
Vasopressin, oxytocin, and neurophysin were measured by RIA in the pituitary, hypothalamus, and plasma (except oxytocin) of the rat during the first month of life. In plasma, vasopressin was less than 1.7 microU/ml in most animals. Neurophysin was elevated above adult levles on day 2 and decreased with age. The three peptides were present in the pituitary at birth, but in amounts less than 1% of the adult level. The vasopressin content of the pituitary increased rapidly in the first days after birth, while the levels of oxytocin and neurophysin remained low until 8 days and then increased between 8-21 days. The ratio of vasopressin to oxytocin in the pituitary was 4.4 at birth and reached unity (the ratio in the adult) at 30 days. At birth, the moles of neurophysin in the pituitary relative to the moles of hormone (oxytocin plus vasopressin) was low (0.15), largely due to a molar excess of vasopressin. The ratio of neurophysin to hormone reached unity at 21-30 days. Assays to detect vasotocin gave negative results. It is postulated that a precursor neurophysin which was related to vasopressin was present in the fetal rat but was not measured in our study.
采用放射免疫分析法（RIA）测定了新生大鼠出生后第一个月垂体、下丘脑和血浆（催产素除外）中血管加压素、催产素和神经垂体素的含量。在大多数动物的血浆中，血管加压素含量低于1.7微单位/毫升。神经垂体素在出生后第2天高于成年水平，并随年龄增长而下降。这三种肽在出生时即存在于垂体中，但含量不到成年水平的1%。垂体中血管加压素的含量在出生后的头几天迅速增加，而催产素和神经垂体素的水平在8天前一直较低，然后在8至21天之间升高。垂体中血管加压素与催产素的比例在出生时为4.4，在30天时达到1（成年时的比例）。出生时，垂体中神经垂体素与激素（催产素加血管加压素）的摩尔比很低（0.15），这主要是由于血管加压素的摩尔过量。神经垂体素与激素的比例在21至30天时达到1。检测加压催产素的试验结果为阴性。据推测，与血管加压素相关的前体神经垂体素在胎鼠中存在，但在我们的研究中未检测到。
