Ciocca D R, González C B
Tissue Cell. 1978;10(4):725-33. doi: 10.1016/0040-8166(78)90058-7.
The epithelium of the pituitary cleft and its colloid have been studied at the ultrastructural level in normal, adrenalectomized, castrated, dehydrated and lactating adult rats. Both control and experimental animals showed cells in different stages of degradation inside the cleft and mixed with the colloid. These exfoliated cells seems to have originated from the cleft's epithelium of the adjacent granular cells. In adrenalectomized and castrated rats the rostral epithelium of the cleft had large intercellular spaces that in some instances appeared to open directly into the cleft. Occasionally, the adenohypophysial canaliculi of the adrenalectomized rats were also seen connecting with the cleft. In lactating and castrated animals dark cells appeared more frequently in the rostral and caudal epithelium of the cleft. The results obtained suggest that the colloids is originated at least in part by involuted pituitary cells. There is also evidence that the follicular cavities of the Pars distalis and the cleft are continuous structures.
在正常、肾上腺切除、去势、脱水和泌乳的成年大鼠中，已在超微结构水平上研究了垂体裂及其胶体。对照动物和实验动物均显示在裂隙内有处于不同降解阶段的细胞，并与胶体混合。这些脱落的细胞似乎起源于相邻颗粒细胞的裂隙上皮。在肾上腺切除和去势的大鼠中，裂隙的 Rostral 上皮有大的细胞间隙，在某些情况下似乎直接通向裂隙。偶尔，也可见肾上腺切除大鼠的腺垂体小管与裂隙相连。在泌乳和去势动物中，深色细胞在裂隙的 Rostral 和尾侧上皮中更频繁出现。所获得的结果表明，胶体至少部分源自退化的垂体细胞。也有证据表明远侧部的滤泡腔和裂隙是连续结构。
