Willis G M, Baker D H
Poult Sci. 1980 Nov;59(11):2538-43. doi: 10.3382/ps.0592538.
Several experiments were conducted with young healthy chicks to investigate the relationship between lasalocid and sulfur-containing amino acids (SAA). Chicks were housed in heated starter batteries in all experiments and were fed, in all but one trial, a completely purified crystalline amino acid diet. As previously determined in our laboratory with monensin, the quantitative requirement for SAA, expressed as a percent of the diet, was neither increased not decreased by 125 mg/kg dietary lasalocid. Unlike that observed with monensin, a consistent and striking SAA X lasalocid interaction was apparent. Hence, lasalocid elicited a marked gain and gain/feed response when added to diets severely deficient in SAA, but it resulted in a marked depression in chick performance when added to diets adequate in SAA. At moderate levels of SAA deficiency, such as those existing in practical corn-soybean meal broiler diets, 125 mg/kg lasalocid neither increased nor decreased rate and efficiency of weight gain. Indeed, no evidence of the SAA X lasalocid interaction was seen when lasalocid was provided in a typical corn-soybean meal chick starter diet.
用年轻健康的雏鸡进行了多项实验，以研究拉沙洛西与含硫氨基酸（SAA）之间的关系。在所有实验中，雏鸡饲养在加热的育雏笼中，除一项试验外，在所有试验中均饲喂完全纯化的结晶氨基酸日粮。正如我们实验室先前用莫能菌素所确定的那样，以日粮百分比表示的SAA定量需求，在日粮中添加125 mg/kg拉沙洛西后，既未增加也未减少。与莫能菌素的情况不同，明显存在一致且显著的SAA×拉沙洛西相互作用。因此，当添加到严重缺乏SAA的日粮中时，拉沙洛西会引起显著的增重和增重/饲料反应，但当添加到SAA充足的日粮中时，它会导致雏鸡生产性能显著下降。在中等程度的SAA缺乏水平下，如实际玉米-豆粕肉鸡日粮中存在的水平，125 mg/kg拉沙洛西既不会增加也不会降低增重速度和效率。事实上，当在典型的玉米-豆粕雏鸡开食日粮中添加拉沙洛西时，未发现SAA×拉沙洛西相互作用的证据。
