Le Charpentier Y, Berry J P, Vacher-Lavenu M C, Tebbi Z, Khellaf M, Lemaigre G, Galle P, Abelanet R
Rev Fr Mal Respir. 1980;8(1):3-10.
Authors report on case of pulmonary alveolar microlithiasis with typical chest X-ray, in a six years old boy (without other case of microlithiasis in his family). Pulmonar biopsy shows numerous heavily mineralised microliths in alveolar lumens. Elementary chemical analysis of the microliths (by micro-probe or "ionic" analysis) detects calcium, phosphorus, potassium, sodium, magnesium and carbon, without any exogenous metal. Study (of decalcified tissue) with electronic microscope shows the substrate of mineralisation to ber made of amorphous, non fibrillar, material. In the center of some microliths, membranous structures (possible of cellular origin) were seen. By histochemical study this substrate seems to be a mucoproteic complex with non-sulfated acid polysaccharide component. Histogenesis of such microliths is therefore discussed.
作者报告了一例六岁男孩的肺泡微石症病例，其胸部X光表现典型（其家族中无其他微石症病例）。肺活检显示肺泡腔内有大量高度矿化的微石。对微石进行的元素化学分析（通过微探针或“离子”分析）检测到钙、磷、钾、钠、镁和碳，未发现任何外源金属。用电子显微镜对脱钙组织进行研究显示矿化基质由无定形、非纤维状物质构成。在一些微石的中心，可见膜状结构（可能起源于细胞）。通过组织化学研究，这种基质似乎是一种含有非硫酸化酸性多糖成分的粘蛋白复合物。因此，对这种微石的组织发生进行了讨论。
