Gardner E C, Hersh T
South Med J. 1981 Feb;74(2):197-9. doi: 10.1097/00007611-198102000-00019.
To determine the frequency of gastrointestinal symptoms in primary hyperparathyroidism, we retrospectively analyzed 100 consecutive patients seen at Emory University Hospital from Jan 1, 1977 through March 1, 1979. At the time of diagnosis, 28 patients complained of nausea, 19 of vomiting, 29 of abdominal pain, and 33 of constipation. One patient presented with acute pancreatitis and 14 had ulcer disease (two gastric and 12 duodenal ulcers). Hypercalcemia increases gastric acid secretion and may account for associated ulcer disease and the ulcer-like pain in primary hyperparathyroidism. The mechanisms causing the other gastrointestinal symptoms in hypercalcemia remain to be elucidated. These symptoms abate on correction of hyperparathyroidism.
为确定原发性甲状旁腺功能亢进症患者胃肠道症状的发生率，我们回顾性分析了1977年1月1日至1979年3月1日期间在埃默里大学医院连续就诊的100例患者。诊断时，28例患者诉恶心，19例诉呕吐，29例诉腹痛，33例诉便秘。1例患者出现急性胰腺炎，14例有溃疡病（2例胃溃疡和12例十二指肠溃疡）。高钙血症会增加胃酸分泌，这可能是原发性甲状旁腺功能亢进症相关溃疡病及溃疡样疼痛的原因。高钙血症导致其他胃肠道症状的机制尚待阐明。甲状旁腺功能亢进症得到纠正后，这些症状会减轻。
