1α-羟胆钙化醇对雏鸡泼尼松龙诱导的肠道钙结合蛋白合成抑制的逆转作用

Reversal of prednisolone-induced inhibition of intestinal calcium-binding protein synthesis by 1 alpha-hydroxycholecalciferol in chicks.

作者信息

Babarykin D A, Rozental R L, Valinietse M Y, Bauman V K, Bogoslovsky N A

出版信息

Tohoku J Exp Med. 1980 Nov;132(3):261-6. doi: 10.1620/tjem.132.261.

DOI:10.1620/tjem.132.261

Abstract

Effects of prednisolone on the biochemical indices of blood serum, ash content in bones, calcium absorption and calcium-binding protein (CaBP) in the intestinal mucosa were studied. The oral administration of prednisolone (10 mg/kg) for 2 weeks reduced CaBP content and calcium absorption to the level typical for D-avitaminosis. The oral administration of 1 alpha-hydroxycholecalciferol (390 pmoles/day) in combination with prednisolone for a week returned calcium absorption and CaBP to the control value.

摘要

研究了泼尼松龙对血清生化指标、骨骼灰分含量、钙吸收以及肠黏膜中钙结合蛋白（CaBP）的影响。口服泼尼松龙（10毫克/千克）2周可使CaBP含量和钙吸收降低至典型的维生素D缺乏症水平。联合口服1α-羟基胆钙化醇（390皮摩尔/天）和泼尼松龙1周可使钙吸收和CaBP恢复至对照值。