Baranov V S, Chebotar' N A
Tsitol Genet. 1980 Nov-Dec;14(6):20-4.
Pyrimethanine (2 and 5 mg/kg) injected to the adult female rats just before ovulation causes significant dose-dependent reduction in embryo cleavage rate. Pyrimethamine administered in a dose of 2 mg/kg before ovulation has no mutagenic effect on 5-day rat embryos, while 5 mg/kg induced chromosomal aberrations in 14.3% of all 5-day embryos as compared to only 6.3 % embryos with chromosomal aberrations in the control animals. The most common types of chrmosomal aberrations induced by pyrimethamine are trisomy and chromosomal mosaicism.
在成年雌性大鼠排卵前注射乙胺嘧啶（2毫克/千克和5毫克/千克）会导致胚胎分裂率出现显著的剂量依赖性降低。排卵前给予2毫克/千克剂量的乙胺嘧啶对5天大的大鼠胚胎没有诱变作用，而5毫克/千克剂量的乙胺嘧啶会使所有5天大胚胎中有14.3%出现染色体畸变，相比之下，对照动物中只有6.3%的胚胎出现染色体畸变。乙胺嘧啶诱导的最常见染色体畸变类型是三体性和染色体镶嵌性。
