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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Crawford M J, Hutson D H

Xenobiotica. 1980 Mar;10(3):187-92. doi: 10.3109/00498258009033744.

The oxidation of the herbicide cyanatryn to cyanatryn S-oxide and de-ethylcyanatryn was used to study S-oxidation and N-de-ethylation in liver microsomes from three species. 2. Both reactions were dependent upon NADPH and were inhibited by methyrapone and CO. However, the enzyme catalysing N-de-ethylation exhibited different species/sex specificity from the S-oxygenase. 3. Rat liver flavoprotein S-oxygenase had no action on cyanatryn, suggesting, with the other data, that the S-oxygenation was catalysed by cytochrome P-450. 4. S-Oxygenation proceeded rapidly in human liver microsomes and the rats was linear for 60 min at 37 degrees C.

利用除草剂氰莠灵氧化生成氰莠灵S-氧化物和脱乙基氰莠灵来研究三种物种肝脏微粒体中的S-氧化和N-脱乙基作用。2. 这两种反应均依赖于NADPH，并被甲吡酮和一氧化碳抑制。然而，催化N-脱乙基作用的酶表现出与S-加氧酶不同的物种/性别特异性。3. 大鼠肝脏黄素蛋白S-加氧酶对氰莠灵无作用，结合其他数据表明，S-氧化是由细胞色素P-450催化的。4. S-氧化在人肝脏微粒体中进行迅速，在大鼠中于37℃下60分钟呈线性。

Crawford M J, Hutson D H

Xenobiotica. 1980 Mar;10(3):187-92. doi: 10.3109/00498258009033744.

The oxidation of the herbicide cyanatryn to cyanatryn S-oxide and de-ethylcyanatryn was used to study S-oxidation and N-de-ethylation in liver microsomes from three species. 2. Both reactions were dependent upon NADPH and were inhibited by methyrapone and CO. However, the enzyme catalysing N-de-ethylation exhibited different species/sex specificity from the S-oxygenase. 3. Rat liver flavoprotein S-oxygenase had no action on cyanatryn, suggesting, with the other data, that the S-oxygenation was catalysed by cytochrome P-450. 4. S-Oxygenation proceeded rapidly in human liver microsomes and the rats was linear for 60 min at 37 degrees C.

利用除草剂氰莠灵氧化生成氰莠灵S-氧化物和脱乙基氰莠灵来研究三种物种肝脏微粒体中的S-氧化和N-脱乙基作用。2. 这两种反应均依赖于NADPH，并被甲吡酮和一氧化碳抑制。然而，催化N-脱乙基作用的酶表现出与S-加氧酶不同的物种/性别特异性。3. 大鼠肝脏黄素蛋白S-加氧酶对氰莠灵无作用，结合其他数据表明，S-氧化是由细胞色素P-450催化的。4. S-氧化在人肝脏微粒体中进行迅速，在大鼠中于37℃下60分钟呈线性。