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少女月经初潮与激素避孕药耐受性——33000例实地研究结果(作者译)

[Menarche of young girls and tolerance of hormonal contraceptives-results of a field study of 33,000 cases (author's transl)].

作者信息

Wenderlein J M

出版信息

Zentralbl Gynakol. 1980;102(17):974-80.

PMID:7467940
Abstract

A field study was undertaken into an oral contraceptive with medium oestrogen content for the purpose of finding out from 13,603 women, aged below 20 years, if correlations with relevance to counselling existed between the age of menarche and acceptance of hormonal contraceptives. Cycles of 34 days and more were recorded from probands in whom menarche had occurred above the age 14 twice as often they had been recordable from probands with early menarche, that is below the age of twelve. Shortened cycles in response to hormonal cycles in response to hormonal contraception were most often recorded from the late-menarche group. -The trend towards heavier withdrawal bleedings and more frequent spottings in women with late menarche should be taken into account, when oral contraceptives are first prescribed. -Growing menarche age was found to be accompanied by growing incidence of mental depression and headache of women who were on the pill. The number of adolescent women with late menarche who reported weight gains in excess of 2 kg was higher than the number of probands with early menarche. Weight gains over the first three months on the pill in the adolescent group were three times as often as in the whole group. -More women with early menarche reported increase in libido. Young women with late menarche wished more of than others to discontinue oral contraception, which seemed to suggest the existence of psychosocial differences between the two groups. The recorded trend towards declining acceptance of oral contraceptives along with growing menarche age may be used for orientation in counselling.

摘要

针对一种雌激素含量中等的口服避孕药进行了一项实地研究,目的是从13603名20岁以下的女性中了解初潮年龄与激素避孕药接受度之间是否存在与咨询相关的关联。月经周期为34天及以上的情况在初潮发生在14岁以上的受试对象中记录到的频率是初潮早(即12岁以下)的受试对象的两倍。对激素避孕药产生反应时月经周期缩短的情况最常出现在初潮较晚的组中。在首次开口服避孕药处方时,应考虑到初潮较晚的女性出现撤退性出血较多和点滴出血较频繁的趋势。发现初潮年龄增长伴随着服用避孕药的女性出现精神抑郁和头痛的发生率增加。初潮较晚的青春期女性中报告体重增加超过2公斤的人数高于初潮较早的受试对象。青春期组在服用避孕药的前三个月体重增加的频率是整个组的三倍。更多初潮较早的女性报告性欲增强。初潮较晚的年轻女性比其他人更希望停止服用口服避孕药,这似乎表明两组之间存在社会心理差异。记录到的随着初潮年龄增长口服避孕药接受度下降的趋势可用于咨询时的指导。

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