Reichelt W, Piepenbrock S, Hempelmann G, Oelert H
Anaesthesist. 1980 Sep;29(9):481-6.
The circulatory effects of Akrinor were investigated in anaesthetized patients during extracorporeal circulation and following open heart surgery. Arterial pressure, cardiac index and the maximal rate of rise of left ventricular pressure increased, whereas the resistance to flow in both circuits and the cardiac filling pressures remained unchanged. The compliance of the extrathoracic capacitance vessels during extracorporeal circulation was unaltered compared with the control group, but the volume content was less after Akrinor (200 ml). If this volume is shifted to the intrathoracic compartment in the intact circulation, the amounts seems too small to explain the increase in cardiac index. This increase and the subsequent rise of the arterial pressure seemed to be due to increased myocardial contractility.
在体外循环期间以及心脏直视手术后，对麻醉患者研究了阿克雷诺（Akrinor）的循环效应。动脉压、心脏指数和左心室压力的最大上升速率增加，而两个循环回路中的血流阻力和心脏充盈压保持不变。与对照组相比，体外循环期间胸外容量血管的顺应性未改变，但使用阿克雷诺（200毫升）后容量含量减少。如果在完整循环中该容量转移至胸内腔室，该容量似乎过小，无法解释心脏指数的增加。这种增加以及随后动脉压的升高似乎是由于心肌收缩力增强所致。
