Lanotte G, Rioux J A, Pratlong F
Ann Parasitol Hum Comp. 1980 Nov-Dec;55(6):635-43.
In the Cévennes focus of visceral leishmaniasis, human cases are equally common in adults and children. A comparative bioclinical study was made of 32 cases of which 17 were children and 15 were adults. Diagnosis of 31 of these cases was made by the demonstration of parasites and one by serological methods. There was a bimodal distribution of ages among the cases 0-8 and 17-76 years). Studies were made in each of these groups of the onset of illness, clinical signs and the level and time of evolution of antibodies demonstrable by the IFAT. Statistical comparisons made with nonparametric tests showed that: 1) The onset of illness was later in adults (a mean of 4 months) than in children (a mean of 1 month). 2) The three main signs (splenomegaly, fever and cutaneous pallor) were predominantly in children (65%) rather than in adults (13%). 3) The level of antibodies was significantly lower in children (59%) less than or equal to 1/160), whereas the high levels (1/1280 and 1/2048) were seen most often in adults (58%).
在塞文山脉内脏利什曼病疫区，成人和儿童的人类病例同样常见。对32例病例进行了一项对比生物临床研究，其中17例为儿童，15例为成人。这些病例中31例通过发现寄生虫确诊，1例通过血清学方法确诊。病例年龄呈双峰分布（0 - 8岁和17 - 76岁）。对每组病例的发病情况、临床体征以及通过间接荧光抗体试验（IFAT）可检测到的抗体水平和演变时间进行了研究。采用非参数检验进行的统计学比较显示：1）成人发病时间（平均4个月）晚于儿童（平均1个月）。2）三个主要体征（脾肿大、发热和皮肤苍白）主要出现在儿童（65%）而非成人（13%）。3）儿童抗体水平（59%小于或等于1/160）显著低于成人，而高抗体水平（1/1280和1/2048）最常出现在成人中（58%）。
