通过粪便胰蛋白酶法筛查囊性纤维化。
Screening for cystic fibrosis by a stool trypsin method.
作者信息
Forrest D C, Wilcken B, Turner G
出版信息
Arch Dis Child. 1981 Feb;56(2):151-3. doi: 10.1136/adc.56.2.151.
Mass screening for cystic fibrosis by a trypsin assay of stool dried on filter paper was evaluated in 20 000 5-day-old babies. Sweat tests were required in only 7 babies. Three of them had cystic fibrosis. The test gave a false-negative result in at least 2 babies, but each had normal pancreatic function. This is not an ideal screening test for cystic fibrosis, as it misses cases with normal pancreatic function, but it is very cheap, highly specific, and appears to be the best currently available screening test.
通过对滤纸上干燥粪便进行胰蛋白酶检测对20000名5日龄婴儿进行囊性纤维化大规模筛查。仅7名婴儿需要进行汗液检测。其中3名患有囊性纤维化。该检测至少在2名婴儿中给出了假阴性结果，但每名婴儿的胰腺功能均正常。这不是囊性纤维化的理想筛查检测，因为它会遗漏胰腺功能正常的病例，但它非常便宜、特异性高，且似乎是目前可用的最佳筛查检测。
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