Peón J, Valenzuela F, Cabrera J, Carrillo G, Aguirre A, Kabela E
Arch Inst Cardiol Mex. 1980 Sep-Oct;50(5):535-43.
Recently, several different models of valvular prostheses have been developed in which biological material, like duramater and perycardium, is being used for their manufacturing. Since these valves have to be manufactured one by one, the possibility of obtaining heterogeneous results is very high, thus it is very important to have a system to evaluate the behavior of these prostheses. The objective of this project was to design and evaluate a cardiac cycle duplicator to test the function of valvular prostheses. The system consists of a double plexiglass chamber, separated by the valvular prosthesis being studied. The superior "auricular" chamber is connected to a reservoir where the height of the column of saline can be modified. The interior "ventricular" chamber is connected to a pump that generates pressure pulses at constant intervals which simulate ventricular systoles. The other end of the pump connects with an artificial Starling's resistance. The data obtained from this system allows the quantification of the following: 1) Functional diameter, form and area of maximal opening; 2) valve motility; 3) sufficiency of the prostheses; 4) velocity of valve opening and closing; 5) rigidity of the valves; 6) optimal pressure gradient for adequate valvular function. The system makes possible the evaluation and comparison of the function of these valvular prostheses.
最近，已经开发出几种不同型号的人工瓣膜，其中使用生物材料（如硬脑膜和心包）来制造这些瓣膜。由于这些瓣膜必须逐个制造，因此获得异质结果的可能性非常高，因此拥有一个评估这些人工瓣膜性能的系统非常重要。该项目的目标是设计和评估一种心动周期复制器，以测试人工瓣膜的功能。该系统由一个双层有机玻璃腔室组成，由正在研究的人工瓣膜隔开。上部的“心房”腔室连接到一个储液器，在那里可以改变盐水柱的高度。内部的“心室”腔室连接到一个泵，该泵以恒定的间隔产生压力脉冲，模拟心室收缩。泵的另一端与一个人工斯塔林电阻相连。从该系统获得的数据可以对以下内容进行量化：1）最大开口的功能直径、形状和面积；2）瓣膜运动；3）人工瓣膜的功能不全；4）瓣膜开闭速度；5）瓣膜的刚度；6）实现足够瓣膜功能的最佳压力梯度。该系统使得评估和比较这些人工瓣膜的功能成为可能。
