Chand N, Altura B M
Artery. 1980;7(3):232-45.
Precise information with respect to whether serotonin (5-HT) exerts direct effects on mammalian pulmonary arteries and veins is lacking. The present studies, using isolated pulmonary arterial strips of dogs and rats, as well as isolated pulmonary veins of dogs, indicate that serotonin exerts direct contractile, but not relaxant, effects on these blood vessels. Contractile responses to 5-HT were not influenced by "specific" receptor-blocking doses of pyrilamine (H1-receptor antagonist), metiamide (H2-receptor antagonist), phentolamine (alpha-adrenoceptor antagonist), propranolol (beta-receptor antagonist), atropine (cholinergic antagonist) or morphine ("M" tryptamine antagonist). These data demonstrate the lack of interaction of 5-HT with either H1- and H2-histamine, alpha and beta-adrenergic, cholinergic, or "M" tryptamine receptors in these pulmonary blood vessels. Selective, competitive antagonism of 5-HT-induced contractions by methysergide (parallel shifts of concentration-effect curves) demonstrate a direct action of 5-HT on D-type serotonin receptors in these pulmonary blood vessels.
关于血清素（5-羟色胺，5-HT）是否对哺乳动物的肺动脉和肺静脉产生直接作用，目前尚缺乏确切信息。本研究使用犬和大鼠的离体肺动脉条以及犬的离体肺静脉，结果表明血清素对这些血管具有直接的收缩作用，而非舒张作用。对5-HT的收缩反应不受“特异性”受体阻断剂量的扑尔敏（H1受体拮抗剂）、甲硫米特（H2受体拮抗剂）、酚妥拉明（α肾上腺素能受体拮抗剂）、普萘洛尔（β受体拮抗剂）、阿托品（胆碱能拮抗剂）或吗啡（“M”色胺拮抗剂）的影响。这些数据表明，在这些肺血管中，5-HT与H1和H2组胺、α和β肾上腺素能、胆碱能或“M”色胺受体之间不存在相互作用。麦角新碱对5-HT诱导的收缩具有选择性、竞争性拮抗作用（浓度-效应曲线平行移动），这表明5-HT对这些肺血管中的D型血清素受体具有直接作用。
