Spina-França A, Salum P N, Limongi J C, Berger A, Losso E R
Arq Neuropsiquiatr. 1980 Dec;38(4):360-6.
A re-evaluation is made of those aspects which led to the etiologic diagnosis in 353 patients who suffered from non-traumatic, non-tumoral myelopathies, and whose cases were studied along a period of 20 years. The cases were distributed as follows: syringomyelia, 5 cases; vascular myelopathy, 15 cases; privation caused myelopathies, 67 cases; infectious or infestation caused myelopathies, 82 cases; post-vaccination, post-infection or post-intoxication, 31 cases; multiple sclerosis and optic neuromyelitis, 20 cases; primary myelopathy, 133 cases. With basis on the diagnosis, those aspects which may contribute to the existing knowledge about physiopathologic mechanisms related to the onset of spinal cord involvement, as related to immunobiologic alterations, are analysed. The role of necrosis, demyelinization and inflammation, and their respective interrelationships are considered in this light.
对353例非创伤性、非肿瘤性脊髓病患者的病因诊断相关方面进行了重新评估，这些病例的研究历时20年。病例分布如下：脊髓空洞症5例；血管性脊髓病15例；营养缺乏性脊髓病67例；感染或寄生虫感染性脊髓病82例；疫苗接种后、感染后或中毒后脊髓病31例；多发性硬化症和视神经脊髓炎20例；原发性脊髓病133例。基于诊断结果，分析了可能有助于现有关于脊髓受累发病相关生理病理机制知识的方面，这些机制与免疫生物学改变有关。据此考虑了坏死、脱髓鞘和炎症的作用及其各自的相互关系。
