大鼠晶状体囊膜组装的研究。高分子量交联胶原成分的生物合成。
Studies on the assembly of the rat lens capsule. Biosynthesis of a cross-linked collagenous component of high molecular weight.
作者信息
Heathcote J G, Bailey A J, Grant M E
出版信息
Biochem J. 1980 Aug 15;190(2):229-37. doi: 10.1042/bj1900229.
Abstract
- Intact rat lenses in tissue culture synthesize hydroxy[3H]proline-containing polypeptides of apparent mol.wt. approx. 180000, which become assembled into aggregates of higher molecular weight with time. 2. Both the 180000-mol.wt. species and the aggregates are components of the deoxycholate-insoluble base-membrane matrix. 3. Formation of the high-molecular-weight aggregate is accompanied by the biosynthesis of the reducible hydroxylysine-derived cross-link hydroxylysino-5-oxo-norleucine. 4. Hydroxylysino-5-oxonorleucine and dehydrohydroxylysinonorleucine are the major reducible cross-links present in intact foetal and 1-month-old calf lens capsules.
摘要
- 组织培养中的完整大鼠晶状体合成表观分子量约为180000的含羟[³H]脯氨酸多肽，随着时间推移，这些多肽会组装成更高分子量的聚集体。2. 分子量为180000的物种和聚集体都是脱氧胆酸盐不溶性基底膜基质的成分。3. 高分子量聚集体的形成伴随着可还原的羟赖氨酸衍生交联物羟赖氨酰-5-氧代-正亮氨酸的生物合成。4. 羟赖氨酰-5-氧代正亮氨酸和脱氢羟赖氨酰正亮氨酸是完整胎儿和1月龄小牛晶状体囊膜中存在的主要可还原交联物。
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