Caramatti C, Mangoni L, Rizzoli V
Ateneo Parmense Acta Biomed. 1980;51(1):57-66.
Clinical studies were undertaken in our Department of Medical Clinic about the therapeutic effects of two associated beta-lactamines in various respiratory infections. 20 patients affected by acute and chronic bronchitis were treated with the following standard protocol: cefadroxil (500 mg) plus dicloxacillin (250 mg) were given simultaneously four times daily for 8 days. For the clinical evaluation of the therapeutic index of drugs, the following parameters were checked in all patients on admission and repeated at the end of treatment: subjective symptoms (dyspnea, cough), fever, WBC count, sedimentation rate, antistreptolysin titre, chest film and the functional indices of hepatic, renal, hemopoietic tissues. To study the pharmacokinetics we measured the amounts of drugs in the body fluids; plasma levels and urinary concentration were determined 6 hours after the first administration of drugs. Our observations show a synergism of action between the cefadroxil and dicloxacillin; the efficacy of this treatment is confirmed in the majority of the patients: 95% of patients affected by acute respiratory infections show a significant decrease in symptoms and 55% a complete recovery.
我们内科门诊开展了关于两种联合使用的β-内酰胺类药物对各种呼吸道感染治疗效果的临床研究。20例急慢性支气管炎患者接受了以下标准治疗方案：头孢羟氨苄（500毫克）加双氯西林（250毫克），每日四次同时给药，持续8天。为了对药物治疗指数进行临床评估，在所有患者入院时检查以下参数，并在治疗结束时重复检查：主观症状（呼吸困难、咳嗽）、发热、白细胞计数、血沉、抗链球菌溶血素滴度、胸片以及肝、肾、造血组织的功能指标。为了研究药代动力学，我们测量了体液中的药物含量；在首次给药6小时后测定血浆水平和尿液浓度。我们的观察结果显示头孢羟氨苄和双氯西林之间存在协同作用；这种治疗方法的疗效在大多数患者中得到证实：95%的急性呼吸道感染患者症状显著减轻，55%完全康复。
