CS-500（ML-236B）对遗传性高脂血症动物模型WHHL兔的降血脂作用。
Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia.
作者信息
Watanabe Y, Ito T, Saeki M, Kuroda M, Tanzawa K, Mochizuki M, Tsujita Y, Arai M
出版信息
Atherosclerosis. 1981 Jan-Feb;38(1-2):27-31. doi: 10.1016/0021-9150(81)90100-3.
PMID:7470202
Abstract
Oral administration of CS-500, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, lowered the serum cholesterol level of both normal and WHHL-rabbits (the first example of heritable hyperlipidemic animals) at doses higher than 5 mg/kg/day. Phospholipids decreased concomitantly, whereas triglycerides did not in either normal or WHHL-rabbits.
摘要
口服CS - 500（一种3 - 羟基 - 3 - 甲基戊二酰辅酶A还原酶的竞争性抑制剂），在剂量高于5毫克/千克/天时，可降低正常兔子和WHHL兔（遗传性高脂血症动物的首个实例）的血清胆固醇水平。正常兔子和WHHL兔的磷脂均随之减少，而甘油三酯则未减少。
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