苯胲和氨基酚对日本鹌鹑的体内作用。

Effects of phenylhydroxylamine and aminophenols in Japanese quail in vivo.

Blaauboer B J, van Holsteijn C W, Wit J G

Xenobiotica. 1980 Jul-Aug;10(7-8):495-8. doi: 10.3109/00498258009033784.

Abstract

The effects of phenylhydroxylamine, and o- and p-aminophenol were studied in the Japanese quail. 2. Symptoms normally observed in aniline-treated birds were seen in quail after phenylhydroxylamine dosage at > 10 mg/kg. Aminophenols (up to 50 mg/kg) did not give these symptoms. 3. Injection of phenylhydroxylamine (50 mg/kg) resulted in formation of 70% ferrihaemoglobin after 5 min, following which a rapid reduction of ferrihaemoglobin was observed. 4. Phenylhydroxylamine reached highest blood concn. of 0.2 mumol/ml after 5 min. Phenylhydroxylamine was reduced to aniline within 5 min. 5. The effects of aniline in vivo are most probably due to O2 shortage caused by ferrihaemoglobin formation.

摘要

研究了苯胲、邻氨基苯酚和对氨基苯酚对日本鹌鹑的影响。2. 给鹌鹑注射剂量大于10mg/kg的苯胲后，出现了通常在苯胺处理的鸟类中观察到的症状。氨基苯酚（高达50mg/kg）未出现这些症状。3. 注射苯胲（50mg/kg）5分钟后，高铁血红蛋白形成率达70%，随后观察到高铁血红蛋白迅速减少。4. 苯胲在5分钟后达到最高血药浓度0.2μmol/ml。苯胲在5分钟内还原为苯胺。5. 苯胺在体内的作用很可能是由于高铁血红蛋白形成导致的氧气短缺。