双氢麦角毒碱对肾上腺素增强的凝血酶诱导的人血小板反应的抑制作用。
Inhibition of adrenaline-potentiated thrombin-induced reaction of human blood platelets by dihydroergotoxine.
作者信息
Barthel W, Hoffmann A, Markwardt F
出版信息
Acta Biol Med Ger. 1978;37(7):1073-9.
PMID:747039
Abstract
The potentiating effect of adrenaline on thrombin-induced aggregation and release reaction of human blood platelets has been studied in vitro. Both reactions are inhibited by low doses of dihydroergotoxine. The inhibition of aggregation is of competitive type. The adrenaline-potentiated thrombin-induced platelet aggregation is inhibited also after intravenous injection of dihydroergotoxine. The pathophysiological implications of these findings are discussed.
摘要
已在体外研究了肾上腺素对凝血酶诱导的人血小板聚集和释放反应的增强作用。低剂量的二氢麦角毒碱可抑制这两种反应。聚集的抑制属于竞争性类型。静脉注射二氢麦角毒碱后，肾上腺素增强的凝血酶诱导的血小板聚集也受到抑制。讨论了这些发现的病理生理学意义。
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