Castro-Tavares J, Garrett J, Gonçalves V
Blood Vessels. 1981;18(1-2):67-74. doi: 10.1159/000158339.
Perinephritic hypertension was induced in mongrel dogs by cellophane encapsulation of one kidney and simultaneous contralateral nephrectomy. Systolic blood pressure began to rise before diastolic blood pressure and both reached maximal values 3 weeks after surgery, their levels becoming stable thereafter up to the end of the study (20 weeks). Cardiac contractility, measured by the index dp/dt/P40 (rate of rise of isovolumic left intraventricular pressure at a developed left ventricular pressure of 40 mm Hg) was not altered during the evolution of hypertension; heart weight and left ventricular thickness were increased. Plasma renin activity markedly decreased in the chronic phase and plasma urea and creatinine levels rised initially in a moderate but significant way, thereafter remaining stable. The structure of the wrapped kidney remained normal 20 weeks after surgery, when microscopic arterial lesions were seen in other organs. The comparison of the evolution of this hypertensive model with other more commonly used renal experimental hypertension types allows us to conclude that cellophane perinephritic hypertension in the dog must be considered as an individual entity.
通过用玻璃纸包裹一侧肾脏并同时切除对侧肾脏，在杂种狗中诱发肾周性高血压。收缩压在舒张压之前开始升高，两者在手术后3周达到最大值，此后直至研究结束（20周）其水平保持稳定。通过指数dp/dt/P40（左心室压力达到40mmHg时等容左心室内压的上升速率）测量的心脏收缩力在高血压发展过程中未发生改变；心脏重量和左心室厚度增加。慢性期血浆肾素活性明显降低，血浆尿素和肌酐水平最初以适度但显著的方式升高，此后保持稳定。手术后20周，被包裹肾脏的结构保持正常，而此时在其他器官中可见微观动脉病变。将该高血压模型的发展与其他更常用的肾性实验性高血压类型进行比较，使我们能够得出结论，狗的玻璃纸肾周性高血压必须被视为一种独立的实体。
