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1
Investigation of action of enkephalin on the spontaneous and evoked release of acetylcholine from rat cortical and striatal slices.脑啡肽对大鼠皮层和纹状体切片中乙酰胆碱自发释放和诱发释放作用的研究。
Br J Pharmacol. 1980;71(1):211-7. doi: 10.1111/j.1476-5381.1980.tb10928.x.
2
Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.脑啡肽类似物和吗啡对脑乙酰胆碱释放的作用：纳洛酮和一种阿片五肽的不同逆转作用
Br J Pharmacol. 1980;71(1):201-10. doi: 10.1111/j.1476-5381.1980.tb10927.x.
3
Depression of potassium-evoked striatal acetylcholine release by delta-receptor activation: inhibition by cholinoactive agents.δ受体激活对钾离子诱发的纹状体乙酰胆碱释放的抑制作用：胆碱能活性药物的抑制作用
Can J Physiol Pharmacol. 1988 Dec;66(12):1487-92. doi: 10.1139/y88-243.
4
The effect of naloxone on opioid-induced inhibition and facilitation of acetylcholine release in brain slices.纳洛酮对阿片类药物诱导的脑片乙酰胆碱释放抑制和促进作用的影响。
Br J Pharmacol. 1982 Jul;76(3):393-401. doi: 10.1111/j.1476-5381.1982.tb09233.x.
5
Ca2+o-independent veratridine-evoked acetylcholine release from striatal slices is not inhibited by vesamicol (AH5183): mobilization of distinct transmitter pools.不依赖Ca2+的藜芦碱诱发的纹状体切片乙酰胆碱释放不受囊泡胺转运体抑制剂（AH5183）的抑制：不同递质池的动员。
J Neurochem. 1991 Jan;56(1):52-8. doi: 10.1111/j.1471-4159.1991.tb02561.x.
6
Release of acetylcholine from rat brain synaptosomes by various agents in the absence of external calcium ions.在无细胞外钙离子的情况下，多种试剂对大鼠脑突触体乙酰胆碱释放的影响
J Physiol. 1984 Aug;353:505-21. doi: 10.1113/jphysiol.1984.sp015348.
7
The effect of opioid drugs on the release of dopamine and 5-hydroxytryptamine from rat striatum following activation of nicotinic-cholinergic receptors.阿片类药物对烟碱型胆碱能受体激活后大鼠纹状体中多巴胺和5-羟色胺释放的影响。
Eur J Pharmacol. 1983 Aug 19;92(1-2):35-42. doi: 10.1016/0014-2999(83)90105-x.
8
Regional release of [3H]dopamine from rat brain in vitro: effects of opioids on release induced by potassium, nicotine, and L-glutamic acid.大鼠脑体外[3H]多巴胺的区域释放：阿片类物质对钾、尼古丁和L-谷氨酸诱导释放的影响。
Can J Physiol Pharmacol. 1983 Jan;61(1):43-60. doi: 10.1139/y83-005.
9
The effects of morphine and methionine-enkephalin on the release of purines from cerebral cortex slices of rats and mice.吗啡和甲硫氨酸脑啡肽对大鼠和小鼠大脑皮层切片中嘌呤释放的影响。
Br J Pharmacol. 1981 Sep;74(1):171-6. doi: 10.1111/j.1476-5381.1981.tb09970.x.
10
Potassium-induced release of enkephalins from rat striatal slices.钾离子诱导大鼠纹状体切片中脑啡肽的释放。
Eur J Pharmacol. 1978 Mar 15;48(2):219-21. doi: 10.1016/0014-2999(78)90331-x.

引用本文的文献

1
Alterations in striatal acetylcholine overflow by cocaine, morphine, and MK-801: relationship to locomotor output.可卡因、吗啡和MK-801对纹状体乙酰胆碱释放的影响：与运动输出的关系。
Psychopharmacology (Berl). 1994 Jul;115(3):297-304. doi: 10.1007/BF02245069.
2
Stereospecific enhancement of evoked release of brain acetylcholine by narcotic antagonists.麻醉拮抗剂对脑乙酰胆碱诱发释放的立体特异性增强作用。
Br J Pharmacol. 1983 Feb;78(2):433-40. doi: 10.1111/j.1476-5381.1983.tb09408.x.
3
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.甲基黄嘌呤对脑啡肽作用于乙酰胆碱释放的拮抗作用：不存在嘌呤联系。
Br J Pharmacol. 1983 Dec;80(4):727-34. doi: 10.1111/j.1476-5381.1983.tb10064.x.

本文引用的文献

1
Effects of morphine and its antagonists on release of cerebral cortical acetylcholine.吗啡及其拮抗剂对大脑皮质乙酰胆碱释放的影响。
Nature. 1970 Oct 10;228(5267):176-7. doi: 10.1038/228176a0.
2
The effect of morphine, nalorphine, naloxone, pentazocine, cyclazocine and oxotremorine on the synthesis and release of acetylcholine by mouse cerebral cortex slices in vitro.吗啡、烯丙吗啡、纳洛酮、喷他佐辛、环佐辛和氧化震颤素对体外培养的小鼠大脑皮层切片乙酰胆碱合成与释放的影响。
Arch Int Pharmacodyn Ther. 1970 Apr;184(2):267-76.
3
Synthesis of radioactive acetylcholine from ( 3 H)choline and its release from cerebral cortex slices in vitro.用（³H）胆碱体外合成放射性乙酰胆碱及其从大脑皮层切片中的释放
J Neurochem. 1971 May;18(5):691-703. doi: 10.1111/j.1471-4159.1971.tb11999.x.
4
Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat.麻醉性镇痛药及拮抗剂对猫大脑皮层乙酰胆碱体内释放的影响。
Br J Pharmacol. 1971 Sep;43(1):53-66. doi: 10.1111/j.1476-5381.1971.tb07156.x.
5
Lack of effect of morphine in reducing the release of labelled acetylcholine from brain slices stimulated electrically.吗啡对电刺激脑片时标记乙酰胆碱释放的减少无作用。
Eur J Pharmacol. 1974 Nov;29(1):192-4. doi: 10.1016/0014-2999(74)90191-5.
6
Inhibition by morphine of the release of [14c]acetylcholine from rat brain cortex slices.吗啡对大鼠大脑皮层切片中[14C]乙酰胆碱释放的抑制作用。
J Pharm Pharmacol. 1969 Aug;21(8):546-7. doi: 10.1111/j.2042-7158.1969.tb08311.x.
7
Regional distribution of opiate receptor binding in monkey and human brain.猴脑和人脑阿片受体结合的区域分布。
Nature. 1973 Oct 26;245(5426):447-50. doi: 10.1038/245447a0.
8
Stimulation by morphine of acetylcholine output from the cerebral cortex of septal rats.吗啡对中隔大鼠大脑皮层乙酰胆碱输出的刺激作用。
Brain Res. 1975 Dec 26;100(3):677-80. doi: 10.1016/0006-8993(75)90168-7.
9
Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro.阿片类激动剂美沙酮、左啡诺及其异构体对体内和体外皮质乙酰胆碱释放的比较作用。
Can J Physiol Pharmacol. 1975 Aug;53(4):540-8. doi: 10.1139/y75-076.
10
Morphine-naloxone interaction in the central cholinergic system: the influence of subcortical lesioning and electrical stimulation.吗啡-纳洛酮在中枢胆碱能系统中的相互作用：皮层下损伤和电刺激的影响
Br J Pharmacol. 1976 Sep;58(1):101-7. doi: 10.1111/j.1476-5381.1976.tb07697.x.

脑啡肽对大鼠皮层和纹状体切片中乙酰胆碱自发释放和诱发释放作用的研究。

Investigation of action of enkephalin on the spontaneous and evoked release of acetylcholine from rat cortical and striatal slices.

作者信息

Jhamandas K, Elliott J

出版信息

Br J Pharmacol. 1980;71(1):211-7. doi: 10.1111/j.1476-5381.1980.tb10928.x.

DOI:10.1111/j.1476-5381.1980.tb10928.x
PMID:7470737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044427/
Abstract

1 The effects of two synthetic enkephalins, D-Ala2-Met5-enkephalinamide (DALA) and D-Ala2-MePhe4-Met5-(0)-ol-enkephalin (33,824) were tested on the spontaneous and stimulated release of acetylcholine (ACh) from rat cortical and striatal slices. 2 DALA, but not 33,824, caused a modest increase in spontaneous cortical ACh release. Neither enkephalin affected the release of cortical ACh induced by high potassium (25 mM) or veratridine (20 microM). 3 DALA had no effect on the release of ACh from striatal slices occurring spontaneously or in the presence of potassium (25 mM), veratridine (5 microM) or ouabain (10 microM). The enkephalin 33,824 also had no significant action on the striatal ACh release except that it caused a slight enhancement of veratridine-evoked release. 4 It is suggested that enkephalins have no significant action on release of ACh from the cortex or striatum in vitro. Their action on ACh release from the cortex in vivo, seen in previous studies, may be exerted at a subcortical level.

摘要

  1. 测试了两种合成脑啡肽，即D - 丙氨酸² - 甲硫氨酸⁵ - 脑啡肽酰胺（DALA）和D - 丙氨酸² - 甲基苯丙氨酸⁴ - 甲硫氨酸⁵ - （O） - 醇 - 脑啡肽（33,824）对大鼠皮质和纹状体切片中乙酰胆碱（ACh）自发释放和刺激释放的影响。

  2. DALA，但不是33,824，导致皮质ACh自发释放适度增加。两种脑啡肽均不影响高钾（25 mM）或藜芦碱（20 μM）诱导的皮质ACh释放。

  3. DALA对纹状体切片中自发或在钾（25 mM）、藜芦碱（5 μM）或哇巴因（10 μM）存在下的ACh释放没有影响。脑啡肽33,824对纹状体ACh释放也没有显著作用，只是它导致藜芦碱诱发的释放略有增强。

  4. 提示脑啡肽在体外对皮质或纹状体中ACh的释放没有显著作用。在先前研究中观察到的它们对体内皮质ACh释放的作用可能在皮质下水平发挥。