电惊厥休克或荷包牡丹碱诱发惊厥后大鼠脑和血清中的钙浓度
Brain and serum calcium concentrations following electroconvulsive shock or bicuculline-induced convulsions in rats.
作者信息
Bowdler J M, Green A R, Rawle F
出版信息
Br J Pharmacol. 1980;71(1):321-5. doi: 10.1111/j.1476-5381.1980.tb10942.x.
1 A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS-treated rats showed an elevated serum concentration 5 min after the ECS. 2 When 5 ECS were given spread out over 10 days there were no significant calcium concentration changes in either serum or brain except for an increase in the pons/medulla. 3 A single convulsion produced by bicuculline (0.375 mg/kg i.v.) resulted in a marked increase in the calcium concentration in serum, but not brain, 5 min later. Diazepam pretreatment (10 mg/kg i.v.) prevented both the convulsion and the serum calcium change. 4 Results are discussed in relation to clinical data on calcium changes following electroconvulsive therapy (ECT) and the enhanced monoamine-mediated behaviours which follow ECS administration to rats.
- 与用氟烷麻醉的大鼠相比，在惊厥后5分钟或24小时，对用氟烷麻醉的大鼠给予单次电惊厥休克（ECS；125V，1秒，50Hz），血清或脑局部钙浓度几乎没有变化。在ECS后5分钟，麻醉和接受ECS治疗的大鼠血清浓度均升高。2. 当在10天内分散给予5次ECS时，除脑桥/延髓增加外，血清或脑中钙浓度没有显著变化。3. 静脉注射荷包牡丹碱（0.375mg/kg）引起的单次惊厥导致5分钟后血清钙浓度显著升高，但脑钙浓度未升高。地西泮预处理（静脉注射10mg/kg）可预防惊厥和血清钙变化。4. 结合电惊厥治疗（ECT）后钙变化的临床数据以及对大鼠给予ECS后增强的单胺介导行为对结果进行了讨论。
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