麻醉灵缇犬冠状动脉闭塞后预防性利多卡因与早期心律失常
Prophylactic lignocaine and early post-coronary artery occlusion dysrhythmias in anaesthetized greyhounds.
作者信息
Marshall R J, Parratt J R
出版信息
Br J Pharmacol. 1980;71(2):597-600. doi: 10.1111/j.1476-5381.1980.tb10978.x.
Abstract
- Lignocaine (1 mg kg-1 min-1 infused intravenously for 30 min) greatly reduced the incidence of ventricular ectopic beats that resulted from acute coronary artery ligation in anaesthetized greyhound dogs. However, the incidence of ventricular fibrillation was only slightly reduced by this treatment which caused significant myocardial depression. 2. There is no good evidence from this study that lignocaine is a particularly effective prophylactic in acute myocardial infarction.
摘要
- 利多卡因（以1毫克/千克/分钟的速度静脉输注30分钟）可显著降低麻醉灵缇犬急性冠状动脉结扎所致室性早搏的发生率。然而，这种导致明显心肌抑制的治疗方法仅使室颤发生率略有降低。2. 本研究没有充分证据表明利多卡因在急性心肌梗死中是一种特别有效的预防性药物。
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Prophylactic lignocaine and early post-coronary artery occlusion dysrhythmias in anaesthetized greyhounds.麻醉灵缇犬冠状动脉闭塞后预防性利多卡因与早期心律失常
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Changes in blood flow and oxygen consumption in normal and ischaemic regions of the myocardium following acute coronary artery ligation.
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