Mitchenere P, Adrian T E, Hobbs K E, Bloom S R
Br J Surg. 1981 Mar;68(3):154-7. doi: 10.1002/bjs.1800680305.
The intraluminal gallbladder pressure has been measured in a conscious unsedated pig model by the use of a radiotelemetry pressure capsule. A loop fistula was incorporated to measure bile output simultaneously. Mean fasting intraluminal gallbladder pressure was found to be 15 +/- 4 mmHg above atmospheric pressure, and mean fasting bile output 7.5 +/- 0.8 ml/10 min. Following intravenous caerulein pressure peaked at 2 min with a mean rise of 17 +/- 3 mmHg above basal (P less than 0.005). Bile output was increased for 30 min following caerulein with a total mean increase for this period of 13.5 +/- 2.2 ml (P less than 0.005). Gallbladder pressure rose significantly 5 min after commencing a meal by 6.0 +/- 1.9 mmHg (P less than 0.025) reaching a peak pressure 65 min after the meal with a mean rise of 14.8 +/- 2.3 mmHg (P less than 0.005). Bile output was significantly increased for 50 min following the ingestion of food. The total increments above basal values for bile output being 15.9 +/- 2.7 ml (P less than 0.005) in the first 30 min post-prandially and 1.6 +/- 2.4 ml (P less than 0.005) in the 30--60 min period. This model re-emphasizes the rapidity of the hormonal response and may be valuable for further studies on the physiology of post-prandial gallbladder emptying.
在清醒未镇静的猪模型中，通过使用无线电遥测压力胶囊测量胆囊腔内压力。纳入一个肠袢瘘以同时测量胆汁分泌量。发现空腹时胆囊腔内平均压力比大气压高15±4 mmHg，空腹时胆汁平均分泌量为7.5±0.8 ml/10分钟。静脉注射缩胆囊素后，压力在2分钟时达到峰值，比基础值平均升高17±3 mmHg（P<0.005）。注射缩胆囊素后胆汁分泌量增加30分钟，在此期间总平均增加量为13.5±2.2 ml（P<0.005）。开始进食后5分钟胆囊压力显著升高6.0±1.9 mmHg（P<0.025），进食后65分钟达到峰值压力，平均升高14.8±2.3 mmHg（P<0.005）。进食后胆汁分泌量显著增加50分钟。餐后前30分钟胆汁分泌量比基础值的总增加量为15.9±2.7 ml（P<0.005），30 - 60分钟期间为1.6±2.4 ml（P<0.005）。该模型再次强调了激素反应的快速性，可能对餐后胆囊排空生理学的进一步研究有价值。
