Häkkinen I P, Heinonen R, Inberg M V, Järvi O H, Vaajalahti P, Viikari S
Cancer Res. 1980 Nov;40(11):4308-12.
A clinicopathological analysis is presented of gastric cancer cases detected in a mass screening trial in Finland, using the oncofetal antigen, fetal sulfoglycoprotein antigen, as a marker. The survey covered a population of 53,020 between the ages of 40 and 70, the percentage of participation being 74.8%. Of these participants, 3,508 subjects (8.8%) were found to be fetal sulfoglycoprotein antigen secretors, and among them 36 gastric cancers, one gastric carcinoid, and 10 tubular adenomas were detected. Both main histological types of gastric cancer, intestinal and diffuse, were represented. There were 15 early cancers. In addition, there were three widely spread superficial cancers. Because of early diagnosis, the prognostic view for these cases is clearly better than that found in the clinic by conventional means, curative resection being carried out in 28 cases (78%).
本文呈现了一项在芬兰进行的大规模筛查试验中检测出的胃癌病例的临床病理分析，该试验使用癌胚抗原——胎儿硫糖蛋白抗原作为标志物。此次调查涵盖了53020名年龄在40至70岁之间的人群，参与率为74.8%。在这些参与者中，发现3508名受试者（8.8%）为胎儿硫糖蛋白抗原分泌者，其中检测出36例胃癌、1例胃类癌和10例管状腺瘤。胃癌的两种主要组织学类型，即肠型和弥漫型，均有出现。有15例早期癌症。此外，还有3例广泛扩散的浅表性癌症。由于早期诊断，这些病例的预后明显优于临床常规方法所发现的情况，28例（78%）进行了根治性切除。
