Mandel R J, Brown M D, McCollough N C, Pallares V, Varlotta R
Clin Orthop Relat Res. 1981 Jan-Feb(154):27-33.
Sixty-eight (68) spinal operations performed under normotensive anesthesia were compared with 77 procedures performed under controlled hypotensive anesthesia. Procedures reviewed included Harrington instrumentation and fusion, dorsal arch resection, laminectomies and other spinal fusions. Intraoperative and postoperative blood loss and blood replacement were found to be reduced by approximately 50% in the group undergoing controlled hypotensive anesthesia for each procedure reviewed. This reduction in blood loss was achieved with only a moderate reduction in blood pressure (20 mm Hg systolic). Reduction in systolic blood pressure of greater than 20 mm was not associated with greater reduction in blood loss. Deliberate hypotension was coupled with hemodilution, lowering the hematocrit to 28% to 30% in order to increase cardiac output, increase tissue perfusion and decrease venous stasis. Autotransfusion has further reduced the need for homologous transfusion such that the combined techniques of hypotension and autotransfusion can eliminate the need for homologous blood transfusion in all but the most unusual cases.
对68例在正常血压麻醉下进行的脊柱手术与77例在控制性低血压麻醉下进行的手术进行了比较。回顾的手术包括哈林顿器械植入和融合术、背弓切除术、椎板切除术及其他脊柱融合术。结果发现,对于所回顾的每一项手术,接受控制性低血压麻醉的组术中及术后失血量和输血量减少了约50%。这种失血量的减少是在血压仅适度降低(收缩压降低20毫米汞柱)的情况下实现的。收缩压降低超过20毫米汞柱与失血量的更大减少无关。控制性低血压与血液稀释相结合,将血细胞比容降至28%至30%,以增加心输出量、增加组织灌注并减少静脉淤滞。自体输血进一步减少了对异体输血的需求,使得低血压和自体输血的联合技术除了在极少数特殊情况下外,可消除对异体输血的需求。