Loo Y, Shin M, Yamashita Y, Ishigami M, Sasaki M, Sano K, Umezawa C
School of Pharmacy, Kobe Gakuin University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1995 Jun;41(3):341-7. doi: 10.3177/jnsv.41.341.
Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome proliferators. The results were discussed in relation to induction of peroxisomal beta-oxidation enzymes by the peroxisome proliferators.
